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Figure 1: The glutamatergic tripartite synapse. Glutamate (Glu) released by the presynaptic neuron binds with both astroglial (MGluR) and postsynaptic neuronal (AMPA and NR2A) receptors. MGluR activate the inositol triphosphate (IP3) pathway, inducing the release of calcium ions from internal stores (mitochondria and endoplasmatic reticulum) to prompt Glu release. Astroglial Glu binds mostly with neuronal NMDA receptors containing the NR2B subunit (NR2B), causing calcium ion entry (slow inward currents) and then sustaining excitatory activity of the postsynaptic neuron (adapted from Pereira and Furlan, 2009).

Figure 1: The glutamatergic tripartite synapse. Glutamate (Glu) released by the presynaptic neuron binds with both astroglial (MGluR) and postsynaptic neuronal (AMPA and NR2A) receptors. MGluR activate the inositol triphosphate (IP3) pathway, inducing the release of calcium ions from internal stores (mitochondria and endoplasmatic reticulum) to prompt Glu release. Astroglial Glu binds mostly with neuronal NMDA receptors containing the NR2B subunit (NR2B), causing calcium ion entry (slow inward currents) and then sustaining excitatory activity of the postsynaptic neuron (adapted from Pereira and Furlan, 2009).