Mens Sana Monographs
EDITORIAL
Year
: 2012  |  Volume : 10  |  Issue : 1  |  Page : 4--12

Psychopharmacology of schizophrenia: The future looks bleak


Chittaranjan Andrade1, Rajiv Radhakrishnan2, Praveen P Fernandes3 
1 M.D. Professor and Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India
2 M.D. Postdoctoral Associate, Dept of Psychiatry, Yale University School of Medicine, New Haven, CT- 06511, USA
3 M.D. Associate Professor of Psychiatry, Department of Psychiatry, Creighton University School of Medicine, 3528 Dodge Street, Omaha, NE 68131, USA

Correspondence Address:
Chittaranjan Andrade
M.D. (Psychiatry), Professor and Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore 560 029
India

Introduction: More than half a century after the introduction of effective pharmacotherapy for the illness, in most patients schizophrenia remains a chronic, relapsing condition with poor long-term outcomes. Methods: We examine the pharmacological treatment of schizophrenia from different perspectives to understand why there have not been significant advances, and to consider what the future might hold in store. Results: We argue that the treatment of schizophrenia addresses the phenotype and not the cause; that the causes may not be treatable even if identifiable; that secondary prevention approaches involving treating the phenotype before full-fledged illness develops have, so far, not yielded promising results; and that shifting the focus of treatment from dopamine to other neurotransmitter systems is merely a tertiary prevention approach which will not reverse the extensive structural and functional pathology of schizophrenia. Conclusions: We believe that, given the current state of our knowledge of the illness, the future of the pharmacotherapy of schizophrenia looks bleak.


How to cite this article:
Andrade C, Radhakrishnan R, Fernandes PP. Psychopharmacology of schizophrenia: The future looks bleak.Mens Sana Monogr 2012;10:4-12


How to cite this URL:
Andrade C, Radhakrishnan R, Fernandes PP. Psychopharmacology of schizophrenia: The future looks bleak. Mens Sana Monogr [serial online] 2012 [cited 2019 Oct 23 ];10:4-12
Available from: http://www.msmonographs.org/article.asp?issn=0973-1229;year=2012;volume=10;issue=1;spage=4;epage=12;aulast=Andrade;type=0