Year : 2010 | Volume
: 8 | Issue : 1 | Page : 17--29
Modern Medicine: Towards Prevention, Cure, Well-being and Longevity
Ajai R Singh
Editor, MSM, 14, Shiva Kripa, Trimurty Road, Nahur, Mulund [W], Mumbai 400 080, India
Ajai R Singh
Editor, MSM, 14, Shiva Kripa, Trimurty Road, Nahur, Mulund [W], Mumbai 400 080
Modern medicine has done much in the fields of infectious diseases and emergencies to aid cure. In most other fields, it is mostly control that it aims for, which is another name for palliation. Pharmacology, psychopharmacology included, is mostly directed towards such control and palliation too. The thrust, both of clinicians and research, must now turn decisively towards prevention and cure. Also, longevity with well-being is modern medicine«SQ»s other big challenge. Advances in vaccines for hypertension, diabetes, cancers etc, deserve attention; as also, the role of meditation, yoga, spirituality etc in preventing disease at various levels. Studies on longevity, life style changes and healthy centenarians deserve special scrutiny to find what aids longevity with wellbeing. A close look at complementary and alternative medicine is needed to find any suitable models they may have, cutting aside their big talk and/or hostility towards mainstream medical care. Medicine is a manifestation of the human eros, and should not become a means of its thanatos. It must realise its true potential, so that eros prevails, and thanatos prevails only ultimately, not prematurely.
|How to cite this article:|
Singh AR. Modern Medicine: Towards Prevention, Cure, Well-being and Longevity.Mens Sana Monogr 2010;8:17-29
|How to cite this URL:|
Singh AR. Modern Medicine: Towards Prevention, Cure, Well-being and Longevity. Mens Sana Monogr [serial online] 2010 [cited 2019 Dec 15 ];8:17-29
Available from: http://www.msmonographs.org/text.asp?2010/8/1/17/58817
I got up with a dream about medicine and was thinking vaguely of analyzing it. And then I thought why, what the heck. Freud is no longer around, and psychoanalysis is not current coin. And life is moving at its nice, leisurely pace, anyway. No major hassles. So why dig?
But a previous early morning dream-realization continues to linger. Let me tell you a bit about it. Modern medicine has progressed, and we must thank the whole bunch of researchers and clinicians for it. But so has pathology. It is not that the number of diseased has reduced, nor has the total quantum of distress related to it. Diseases, and the afflicted, are not reducing in numbers; they are only changing in type (Singh and Singh, 2005). No doubt, we have increased longevity, made old age livable, reduced infant mortality, made everyday living itself more distress-free by the numerous medicines/procedures in our armoury; but we have not reduced the number of diseased, nor found cures for any diseases except the infectious; as also of course some remarkable successes with emergency care. [Both, great mobilization of resources and energies towards reducing social distress. Just as an animal, human included, will struggle and strain to cope with emergencies, especially a threat to life or limb, similarly as though the society-animal has developed efficient methods to cope with its emergencies. So methods to tackle infections and acute medical/surgical problems are really efficient.]
In the case of most other medical care, it is mainly control -- slowing advance, reducing distress, minimizing disability, prolonging death.
It is passι to think in terms of cure, as though it were a hate-word.
Modern Medicine Mostly Palliative
Modern medicine is mostly palliative, and rather proud of it. By palliation, I am not talking of cancers. I mean reducing or easing the severity of a pain or a disease without removing the cause, or effecting a cure (from Latin palliare, to cloak).
In other words, control.
It is rather like making a virtue out of a necessity and also, false bravado.
What medicine needs to do is propel towards cure on one hand and prevention on the other. Cure, however, is out of consideration, because it appears unachievable, and prevention is nowhere in the collective consciousness of biomedical researchers and opinion makers, I suspect probably because it would ultimately make them redundant. And the cure and prevention lobby makes only weak noises, if at all, and does not have the clout to change mainstream opinion.
What this ultimately means is that while the truth is there for all to see, and work over, it does not get done. Why should it be so? Is it because mankind is propelled by a recklessly driven thanatos, as Freud said? That it will deny, and prevent realizations that matter, because it must propel itself towards decay and ultimate death, even as it ostensibly appears to be fighting it all the time by its many heroic and sustained manoeuvers?
Let me put it a little differently. What should the modern doctor be doing? He should either prevent a disease so it does not occur, or cures it if it does. What does the modern doctor, me included, do? He neither prevents, nor cures in any but a few conditions. He only controls spread of the disease, and palliates while so doing. His motto can be captured in a sentence: To cure sometimes, to comfort always, to hurt the least, to harm never (Singh and Singh, 2005).
The epitome of palliation, true, but not of cure, or prevention.
This realization does not propel him towards cure or prevention. It propels him towards greater and more efficient palliation. As though to quickly rid him of the realization that must stare him in the face, and expose his nakedness before all, and most importantly, his own consciousness.
What Do We Do? Eros Guides, Thanatos Ultimately Prevails
So what do we do? It would be convenient, but facile, to accept Freud's formulation. That thanatos and eros are the two instincts that rule our life, and that thanatos does, and must, ultimately prevail, for the ultimate reality is death, whatever manoeuvers one may carry out to prevent it. Which explains why modern medicine's propulsion is towards control, not cure or prevention: it is just one manifestation of this thanatos.
That of course, does not mean we do not exercise eros, for it will exercise itself anyway. And medicine's palliative goals are but one manifestation of this exercise.
This is an effective, but weak, eros. But in not making cure and prevention its goals, medicine as though accepts the inevitability of a thanatos to rule over its efforts.
Medicine, on the other hand, has to become the most glorious manifestation of an eros that prevents/cures disease and promotes well-being in its best possible form. This will be an effective, and strong, eros.
Till death occurs. Which it will.
When, ultimately, thanatos prevails.
Which can lead us to ask the question: If ultimately death had to prevail, why exercise eros at all? Why not accept the reality and stop fighting thanatos, rather accept it willingly?
The answer is that thanatos prevails only ultimately. It is the interim which really matters - the interval between life and death. What we do with it alone is in our hands, and that's where the whole human effort is directed, and legitimately so. Hence eros must be consciously, and vigorously, promoted. Why allow what must occur only at the end to override this process?
The key concept is ultimately. Not prematurely, not unobtrusively as it does today, due to our lack of directedness.
As also the realization that if ultimately thanatos must prevail, one must know when to give way, and stop struggling too, to ensure a dignified exit. The whole expenditure of human resources to avoid the inevitable when it has to occur will then stop. Modern medicine's role of helplessness mixed with grandiosity that promotes life at any cost e.g. in persistent vegetative states, will then end.
An eros must guide our consciousness, and our efforts, even as we accept the truth of a thanatos, which must ultimately prevail.
Prevention and Cure, the Watchwords
If we accept this, the path before us is very clear.
The first goal of medicine is to see to it that no one has to reach a hospital or a clinic. This is what I mean by prevention. [Technically called primary prevention; not of course ruling out the importance of secondary prevention (early detection and prompt treatment) and tertiary prevention (restoring function and reducing disability)]. This should be the very first goal, not the last; which means, health promotion/education activities along with clean water, nutritious food, clean and disaster free habitation, proper sanitation, control of pollution, poverty alleviation, empowerment of the deprived and disadvantaged, life-style modifications. A tall order, which involves multiple agencies, not in control of medicine and its movers. That is one prime reason why it is not top of the agenda, perhaps. And of course because it cuts at the very root of the justification for the medical establishment, and its proliferation. But medicine has as much a treatment orientation as a social perspective. For health is a means to well-being, and health can be achieved for all only when all are mobilized for health and become conscious of what should be its legitimate thrust (Singh and Singh, 2004). Moreover, prevention, understood as preventing a disease from occurring, also means, finding out vaccines, and other preventive measures, for all its diseases, not just the infectious. Let this stop sounding ludicrous. It is comforting to note that work on vaccines is underway, especially for diabetes (Phillips et al., 2008; Richardson et al., 2009), hypertension (Mitka, 2007; Ambόhl et al., 2007; Phisitkul, 2009), cancers (especially cervical: Jenkins, 2008; Keam and Harper, 2008; Schwarz, 2008), and at least suggested for schizophrenia and other mental disorders (Tomlinson et al., 2009). And, related to this, it must research and highlight life style changes which prevent disease, and tackle diseases of poverty and of lifestyle (Singh and Singh, 2008). Some work in this field is already on, for example, in cancers (Anand et al., 2008), Type 2 Diabetes (Misra, 2009), cardiovascular disease (Pischke et al., 2008), ulcerative colitis (Langhorst et al., 2007); as also the beneficial effects of a vegetarian diet in lifestyle diseases (Segasothy and Phillips, 1999). Preventive psychiatry also needs a boost, for psychiatry, and overall for medicine, for do we not know that psychological distress is at the root of common medical problems that reach a primary care physician, and complicate many manifestations of other disorders at all levels of their manifestation. The complex relationships between gene-environment interactions, particularly the interplay of vulnerability and resilience factors within a person's biography need close scrutiny in individualized preventive psychiatry (Mόller-Spahn, 2008), as does reduction of stigma in secondary prevention (Reeder and Pryor, 2008). The role of health psychology and the related field of behavioural medicine which focus on the interplay among biological dispositions, behaviour, and social context also need enthusiastic backing as a means to health promoting behaviours and preventing health damaging ones (Kaplan, 2009). Modern medicine must look closely at, and not pooh pooh, the claims of alternative and complementary medicine, including yoga, meditation and spirituality, just because one is put off by their tall sounding claims, and some charlatans in the group. Rather, it must submit their claims to rigorous scientific and experimental scrutiny. Some recent studies in yoga in general (Lipton, 2008; Bijlani, 2008; Corliss, 2001; Oken et al., 2006; Brown and Gerbarg, 2005; Shapiro et al., 2007; Flegal et al. 2007), and yoga in cancers (Culos-Reed et al., 2006; Bower et al., 2005; Smith and Pukall, 2009; Danhauer et al., 2009) are promising in this direction. Studies of meditation as an adjunct to modern medicine deserve special mention here. Some promising leads are in works on Longevity and health through yogic meditation (Bushell, 2009), and meditation in general (Bushell and Thiese, 2009); meditative practices for health (Ospina et al., 2007), and their clinical trials (Ospina et al., 2008); Sudarshan kriya in stress, anxiety and depression (Brown and Gerbarg, 2009); Transcendental Meditation and longevity (Alexander et al., 1989); meditation and slowing of aging, (Epel et al., 2009); mindfulness and distress (Jain et al., 2007); and mindfulness and well-being (Shapiro et al., 2008). Spirituality and its various scientific studies need a close scrutiny too. Some areas of spirituality which have interested researchers in recent times are positive emotions and spirituality (Vaillant, 2008), its neurobiology (Mohandas, 2008), healing presence (McDonough-Means et al., 2004), spiritual encounter and complementary treatment (Foster, 2006), spirituality and psychiatry (Mohr, 2006), health and spirituality in critical care (Puchalski, 2004), spirituality and critical care holistic nursing (Carpenter et al., 2008), difficulty in talking about spirituality in a medical setting (Molzahn and Sheilds, 2008) etc. To promote rigorous scientific scrutiny of claims in Complementary and Alternative medicine [CAM], laudable efforts are on by relatively new Journals in the field like Evidenced Based Complementary and Alternative Medicine (an Oxford Journal, since June 2004, http://ecam.oxfordjournals.org ), BMC Complementary and Alternative Medicine (Published by BioMed Central, since 2001, http://www.biomedcentral.com/bmccomplementalternmed ), Alternative Therapies in Health and Medicine (since 1995, first journal in the field of CAM to be indexed with NLM http://www.alternative-therapies.com ), Journal of Alternative and Complementary Medicine (since 1995, Official Journal of the International society for Complementary Medicine Research, http://www.liebertpub.com/products/product.aspx?pid=26 ). Some notable relatively recent work in CAM in the field in anxiety and depression (van der Watt et al., 2008), depression in women (Manber et al., 2002), menopausal women (Kronenberg and Fugh-Berman, 2002), sleep disorders in the elderly (Gooneratne, 2008), osteoarthritis (Ernst, 2006), asthma (Pretorius, 2009) etc, should not go unnoticed. And while all this happens, the preventive and social medicine guys from mainstream medicine need to awaken and clean up their act. To stop being sidelined, and point out how they matter. And of course, to re-emphasize that prevention is better than cure (Phakathi, 2009, where it is in relation to child sexual abuse, but applicable elsewhere too).
The second goal is to cure disease/s if he lands up in a hospital/clinic, so the patient does not land with the same disease/s again. Or with related ones. And lands up lesser in hospitals and more at workplaces and homes. For this, the emphasis must shift from control to cure, even if we know it is a distant goal today. Distant does not make it unachievable. In fact distant must make clear how much more need be done, and in which direction. I would have loved to add a list of references here, but am sorry to find very little of any consequence.
Longevity and well-being
The third is to closely study and report on longevity and well-being studies. Well-being implies the presence of (1) positive emotions and the absence of negative ones; (2) mature character traits, including self-directedness, cooperativeness, and self-transcendence; (3) life satisfaction or quality of life; and (4) character strengths and virtues, such as hope, compassion, and courage, all of which are now measurable by scales (Cloninger, 2008). Some relatively recent literature focuses on telomeres and longevity (Haussmann and Mauck, 2008); sex differences in longevity, (Franceschi et al., 2000); Immunology and longevity (Candore et al., 2006); psychosocial factors and longevity (Darviri et al., 2009) etc. The paradigm of Reorganizational healing [ROH] is an interesting recent work in the field of wellness, behaviour change, holistic practice and healing (Epstein et al., 2009). Anyone who has not visited a hospital and is over 60 years is a precious commodity to research. Anyone who has none of the lifestyle diseases till 60 is also similarly precious. All those who are 90 and active physically and mentally, even if diseased, form another very precious group. And all centenarians are the most precious group to study. It is fascinating to see the breadth of studies on this topic. There is a burgeoning research on centenarians in the last decade, some of promise and interest are in the areas of Centenarians and healthy aging (Engberg et al., 2009); antioxidants and healthy centenarians (Mecocci et al., 2000); nonagenarians and centenarians in China, (Ye et al., 2009); centenarians in Bama (Xiao et al., 1996); quality of life and longevity, (Jeune, 2002); Danish centenarians, not necessarily healthy but still autonomous (Andersen-Ranberg et al., 2001); and not necessarily having dementia, (Andersen-Ranberg et al., 2006); centenarians and their cognitive functions, (Silver et al., 2001); dementia free centenarians (Perls, 2004a, 2004b); centenarians being different (Perls 2006); cognitive states of Centenarians, (Luczywek et al., 2007); successful aging in centenarians: myths and reality, (Motta et al., 2005); physical activity and centenarians (Antonini et al., 2008); centenarians aging gracefully (Willcox et al., 2007) etc.
Pharmacology as a tool to prevention, cure and well-being
Pharmacology is a very potent tool, but most of it is directed towards palliation and control at present. It must be marshaled towards cure and prevention. This is its big challenge, if it can transcend economic compulsions and awaken to its true role in medicine. Psychopharmacology is similar, but, additionally, it needs greater help from clinical and investigative diagnostics to help psychiatry become a full-fledged medical discipline from its interim status at present (Singh and Singh, 2009). Although it has mainly developed newer drugs that are more tolerable rather than better in efficacy, it has also helped reduce stigma and made primary care physicians more comfortable in treating mental disorders (Schwartz, 2010).
Paradigm shift from control/palliation to prevention/cure
The thrust and focus must shift from control/palliation to cure and prevention. The ultimate goal is longevity with well-being, of which freedom from disease is a very important ingredient. Major research funding must guide these efforts, even as we do not neglect greater refinements in modern 'palliative' medicine.
The master winces as he smiles
The course is clear. The goal is set.
Shall we try and get the bandwagon moving?
The other course is of course to awaken from a slumber with a dream and remember the great master and his strivings to understand the fundamentals of disease, as he talked of dream analysis and the unconscious; to quieten the realization with a denial that is so characteristic of much of modern medicine, as also pharmacology, psychopharmacology included. And lapse into a slumber that pushes uncomfortable dreams into realms that work to energize the thanatos and propel man to his inevitable end.
You decide what to do.
The master smiles wryly, even as he turns wincing with pain in his grave.
Let's turn the course from palliation and control to prevention and cure. Let's first think it's possible.This is the future goal of pharmacology, including psychopharmacology, as it is of medical practice and research.To ensure longevity with well-being, let's not discount the work of complementary and alternative medicine. Rather submit them to rigorous scientific scrutiny.We also need to promote longevity studies. Take home message
A paradigm shift in mainstream medicine from control and palliation to prevention and cure must prevail. The ultimate goal is longevity with well-being.
Conflict of interest
This is my original unpublished piece, not under consideration for publication elsewhere. [Figure 1]
Questions That This Paper Raises
What needs to be done to bring about the paradigm shift from control and palliation to prevention and cure?Is cure at all possible?Will mainstream medicine ever be able to incorporate the beneficial findings of CAM?Will prevention and cure strike at the very legitimacy of the proliferation of the medical establishment, and therefore never assume top priority, even as we give lip service to it?What needs to be done to promote wellness with longevity?How do we propel medicine to become a means of an effective and strong eros, rather than an effective but weak one as at present?
About the Author
[AUTHOR:1]Ajai R. Singh M.D. is a Psychiatrist and Editor, Mens Sana Monographs, ( http://www.msmonographs.org ). He has written extensively on issues related to psychiatry, philosophy, bioethical issues, medicine, and the pharmaceutical industry.
|1||Alexander C.N., Langer E.J., Newman R.I., Chandler H.M., Davies J.L., (1989), Transcendental meditation, mindfulness, and longevity: an experimental study with the elderly, J Pers Soc Psychol, 57 (6), p950-964.|
|2|| Ambόhl P.M., Tissot A.C., Fulurija A., Maurer P., Nussberger J., Sabat R., Nief V., Schellekens C., Sladko K., Roubicek K., Pfister T., Rettenbacher M., Volk H.D., Wagner F., Mόller P., Jennings G.T., Bachmann M.F., (2007), A vaccine for hypertension based on virus-like particles: preclinical efficacy and phase I safety and immunogenicity, J Hypertens, 25 (1), p63-72.|
|3|| Anand P., Kunnumakkara A.B., Sundaram C., Harikumar K.B., Tharakan ST., Lai OS., Sung B., Aggarwal BB., (2008), Cancer is a preventable disease that requires major lifestyle changes, Pharm Res, 25 (9), p2097-2116.|
|4|| Andersen-Ranberg K., Schroll M., Jeune B., (2001a), Healthy centenarians do not exist, but autonomous centenarians do: a population-based study of morbidity among Danish centenarians, J Am Geriatr Soc, 49 (7), p900-908.|
|5|| Andersen-Ranberg K., Vasegaard L., Jeune B., (2001b), Dementia is not inevitable: a population-based study of Danish centenarians, J Gerontol B Psychol Sci Soc Sci, 56 (3), p152-159.|
|6|| Antonini F.M., Magnolfi S.U., Petruzzi E., Pinzani P., Malentacchi F., Petruzzi I., Masotti G., IMUSCE., (2008), Physical performance and creative activities of centenarians, Arch Gerontol Geriatr, 46 (2):253-61. Epub 2007 Jun 4.|
|7|| Bijlani R.L., (2008), Yoga: an ancient tool in modern medicine, Natl Med J India, 21 (5), p215-216. |
|8||Bower J.E., Woolery A., Sternlieb B., Garet D., (2005), Yoga for cancer patients and survivors, Cancer Control, 12 (3), p165-171.|
|9|| Brown R.P., Gerbarg P.L., (2005), Sudarshan Kriya Yogic breathing in the treatment of stress, anxiety, and depression. Part II--clinical applications and guidelines, J Altern Complement Med, 11 (4), p711-717.|
|10|| Brown R.P., Gerbarg P.L., (2009), Yoga breathing, meditation, and longevity, Ann N Y Acad Sci., 1172, p54-62.|
|11|| Bushell W.C., (2009), Longevity: potential life span and health span enhancement through practice of the basic yoga meditation regimen, Ann N Y Acad Sci, 1172, p20-27.|
|12|| Bushell W.C., Theise N.D., (2009), Toward a unified field of study: longevity, regeneration, and protection of health through meditation and related practices, Ann N Y Acad S., 1172 , p5-19. |
|13||Candore G., Balistreri C.R., Listμ F., Grimaldi M.P., Vasto S., Colonna-Romano G., Franceschi C., Lio D., Caselli G., Caruso C., (2006), Immunogenetics, gender, and longevity, Ann N Y Acad Sci, 1089 , p516-537. |
|14||Carpenter K., Girvin L., Kitner W., Ruth-Sahd L.A., (2008), Spirituality: a dimension of holistic critical care nursing, Dimens Crit Care Nurs, 27(1), p16-20.|
|15|| Cloninger C.R., (2008), On Well-Being: Current Research Trends And Future Directions (Ed), MSM, 6(1), p3-9.|
|16|| Corliss R., (2001), The power of yoga, Time, Apr 23, 157 (16), p54-63.|
|17|| Culos-Reed S.N., Carlson L.E., Daroux L.M., Hately-Aldous S., (2006), A pilot study of yoga for breast cancer survivors: physical and psychological benefits, Psychooncology, 15( 10), p891-897.|
|18|| Danhauer S.C., Mihalko S.L., Russell G.B., Campbell C.R., Felder L., Daley K., Levine E.A., (2009), Restorative yoga for women with breast cancer: findings from a randomized pilot study, Psychooncology, 18 (4), p360-368.|
|19|| Darviri C., Demakakos P., Tigani X., Charizani F., Tsiou C., Tsagkari C., Chliaoutakis J., Monos D., (2009), Psychosocial dimensions of exceptional longevity: a qualitative exploration of centenarians' experiences, personality, and life strategies, Int J Aging Hum Dev, 69 (2), p101-118. |
|20||Engberg H., Oksuzyan A., Jeune B., Vaupel J.W., Christensen K., (2009), Centenarians--a useful model for healthy aging? A 29-year follow-up of hospitalizations among 40,000 Danes born in 1905, ing Cell, 8 (3), p270-276. Epub 2009 Mar 27.|
|21|| Epel E., Daubenmier J., Moskowitz J.T., Folkman S., Blackburn E., (2009), Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres, Ann N Y Acad Sci, 1172 , p34-53.|
|22|| Epstein D.M., Senzon, S.A., Daniel Lemberger D.A., (2009), Reorganizational Healing:A Paradigm for the Advancement of Wellness, Behavior Change, Holistic Practice, and Healing, Jr Altern Complement Med, 15 (5), p 475-487.|
|23|| Ernst E., (2006), Complementary or alternative therapies for osteoarthritis, Nat Clin Pract Rheumatol., 2 (2), p74-80.|
|24|| Flegal K.E., Kishiyama S., Zajdel D., Haas M., Oken B.S., (2007), Adherence to yoga and exercise interventions in a 6-month clinical trial, BMC Complement Altern Med, 7 , p37.|
|25|| Foster E., (2006), The spiritual encounter within a complementary therapy treatment, Complement Ther Clin Pract, 12 (2), p163-169. Epub 2005 Oct 5. |
|26||Franceschi C., Motta L., Valensin S., Rapisarda R., Franzone A., Berardelli M., Motta M., Monti D., Bonafθ M., Ferrucci L., Deiana L., Pes G.M., Carru C., Desole M.S., Barbi C., Sartoni G., Gemelli C., Lescai F., Olivieri F., Marchegiani F., Cardelli M., Cavallone L., Gueresi P., Cossarizza A., Troiano L., Pini G., Sansoni P., Passeri G., Lisa R., Spazzafumo L., Amadio L., Giunta S., Stecconi R., Morresi R., Viticchi C., Mattace R., De Benedictis G., Baggio G., (2000), Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE), Aging (Milano), 12 (2), p77-84. |
|27||Gooneratne N.S., (2008), Complementary and alternative medicine for sleep disturbances in older adults, Clin Geriatr Med, 24 (1), p121-38, viii. |
|28||Haussmann M.F., Mauck R.A., (2008), Telomeres and longevity: testing an evolutionary hypothesis, Mol Biol Evol, 25 (1), p220-228. Epub 2007 Dec 10.|
|29|| Jain S., Shapiro S.L., Swanick S., Roesch S.C., Mills P.J., Bell I., Schwartz G.E., (2007), A randomized controlled trial of mindfulness meditation versus relaxation training: effects on distress, positive states of mind, rumination, and distraction, Ann Behav Med, 33 (1), p11-21.|
|30|| Jenkins D., (2008), A review of cross-protection against oncogenic HPV by an HPV-16/18 AS04-adjuvanted cervical cancer vaccine: importance of virological and clinical endpoints and implications for mass vaccination in cervical cancer prevention, Gynecol Oncol, 110 (3 Suppl 1), s18-25. |
|31||Jeune B., (2002), Living longer--but better? Aging Clin Exp Res, 14 (2), p72-93 . |
|32|| Kaplan R.M., (2009), Health Psychology: Where Are We And Where Do We Go From Here? MSM, 7 , p3-9. |
|33||Keam S.J., Harper DM., (2008), Human papillomavirus types 16 and 18 vaccine (recombinant, AS04 adjuvanted, adsorbed) [Cervarix], Drugs, 68 (3), p359-372. |
|34|| Kronenberg F., Fugh-Berman A., (2002), Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials, Ann Intern Med, 137 (10), p805-813. |
|35||Langhorst J., Mueller T., Luedtke R., Franken U., Paul A., Michalsen A., Schedlowski M., Dobos GJ., Elsenbruch S., (2007), Effects of a comprehensive lifestyle modification program on quality-of-life in patients with ulcerative colitis: a twelve-month follow-up, Scand J Gastroenterol, 42 (6), p734-745.|
|36||Lipton L., (2008), Using yoga to treat disease: an evidence-based review, JAAPA, 21 (2), p34-6, 38, 41.|
|37|| Luczywek E., Gabryelewicz T., Barczak A., Religa D., Pfeffer A., Styczynska M., Peplonska B., Chodakowska-Zebrowska M., Barcikowska M., (2007), Neurocognition of centenarians: neuropsychological study of ιlite centenarians, Int J Geriatr Psychiatry, 22 (10), p1004-1008. |
|38||McDonough-Means SI., Kreitzer M.J. Bell I.R., (2004), Fostering a healing presence and investigating its mediators, J Altern Complement Med, 10, Suppl 1, pS25-41.|
|39|| Manber R., Allen J.J., Morris M.E., (2002), Alternative treatments for depression: empirical support and relevance to women, J Clin Psychiatry, 63 (7), p628-40.|
|40|| Mecocci P., Polidori M.C., Troiano L., Cherubini A., Cecchetti R., Pini G., Straatman M., Monti D., Stahl W., Sies H., Franceschi C., Senin U., (2000), Plasma antioxidants and longevity: a study on healthy centenarians, Free Radic Biol Med, 28 (8), p1243-1248.|
|41|| Misra A., (2009), Prevention of type 2 diabetes: the long and winding road, The Lancet, 374 (9702), p1655 - 1656.|
|42|| Mitka M., (2007), Vaccine takes aim at hypertension, JAMA, 298 (24), p2854-2855.|
|43|| Mohandas E., (2008), Neurobiology of Spirituality, MSM, 6 (1), p63-80.|
|44|| Mohr W.K., (2006), Spiritual issues in psychiatric care, Perspect Psychiatr Care, 42 (3), p174-183. |
|45||Molzahn A.E., Sheilds L., (2008), Why is it so hard to talk about spirituality? Can Nurse, 104(1), p25-29.|
|46|| Motta M., Bennati E., Ferlito L., Malaguarnera M., Motta L., Italian Multicenter Study on Centenarians (IMUSCE), (2005), Successful aging in centenarians: myths and reality, Arch Gerontol Geriatr, 40 (3), p241-51.|
|47|| Mόller-Spahn F., (2008), Individualized preventive psychiatry: syndrome and vulnerability diagnostics, Eur Arch Psychiatry Clin Neurosci, 258, Suppl 5:92-7.|
|48|| Oken B.S., Zajdel D., Kishiyama S., Flegal K., Dehen C., Haas M., Kraemer D.F., Lawrence J., Leyva J., (2006), Randomized, controlled, six-month trial of yoga in healthy seniors: effects on cognition and quality of life, Altern Ther Health Med, 12 (1), p40-47. |
|49||Ospina M.B., Bond K., Karkhaneh M.,Tjosvold L., Vandermeer B., Liang Y., Bialy L., Hooton N., Buscemi N., Dryden D.M., Klassen T.P., (2007) , Meditation practices for health: state of the research, Evid Rep Technol Assess (Full Rep), 155, p1-263.|
|50|| Ospina M.B., Bond K., Karkhaneh M., Buscemi N., Dryden D.M., Barnes V.,Carlson LE., Dusek J.A., Shannahoff-Khalsa D., (2008), Clinical trials of meditation practices in health care: characteristics and quality, J Altern Complement Med, 14 (10), p1199-1213.|
|51|| Perls T., (2004a), Dementia-free centenarians, Exp Gerontol, 39 (11-12), p1587-1593.|
|52|| Perls T., (2004b), Centenarians who avoid dementia, Trends Neurosci, 27 (10), p633-636.|
|53|| Perls T.T. (2006), The different paths to 100, Am J Clin Nutr, 83 (2), p484S-487S.|
|54|| Phakathi M., (2009) , Prevention is better than cure, Bull World Health Organ, 87 (5), p328-329.|
|55|| Phillips B., Nylander K., Harnaha J., Machen J., Lakomy R., Styche A., Gillis K., Brown L., Lafreniere D., Gallo M., Knox J., Hogeland K., Trucco M., Giannoukakis N., (2008), A microsphere-based vaccine prevents and reverses new-onset autoimmune diabetes, Diabetes, 57 (6), p1544-1555.|
|56|| Phisitkul S., (2009), CYT-006-AngQb, a vaccine against angiotensin II for the potential treatment of hypertension, Curr Opin Investig Drugs, 10 (3), p269-275. |
|57||Pischke C.R., Scherwitz L., Weidner G., Ornish D., (2008), Long-term effects of lifestyle changes on well-being and cardiac variables among coronary heart disease patients, Health Psychol, 27 (5), p584-92.|
|58|| Pretorius E., (2009), The role of alternative and complementary treatments of asthma, Acupunct Electrother Res, 34 (1-2), p15-26.|
|59|| Puchalski C., (2004), Spirituality in health: the role of spirituality in critical care, Crit Care Clin, 20 (3), p487-504, x. |
|60||Reeder G.D., Pryor J.B., (2008), Dual Psychological Processes Underlying Public Stigma and the Implications for Reducing Stigma, MSM, 6 (1), p175-186.|
|61|| Richardson S.J., Willcox A., Bone A.J., Foulis A.K., Morgan N.G., (2009), The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes, Diabetologia, 52(6), p1143-51.|
|62|| Schwarz T.F., (2008), AS04-adjuvanted human papillomavirus-16/18 vaccination: recent advances in cervical cancer prevention, Expert Rev Vaccines, 7(10), p1465-1473.|
|63|| Schwartz T.L., (2010), Psychopharmacology today: Where are we and where do we go from here? (Ed), MSM, 8 . [In press].|
|64||Segasothy M., Phillips P.A., (1999), Vegetarian diet: panacea for modern lifestyle diseases? Q J Med, 92, p531-544. |
|65||Shapiro D., Cook I.A., Davydov D.M., Ottaviani C., Leuchter A.F., Abrams M., (2007), Yoga as a Complementary Treatment of Depression: Effects of Traits and Moods on Treatment Outcome, Evid Based Complement Alternat Med., 4 (4), p493-502.|
|66|| Shapiro S.L., Oman D., Thoresen C.E., Plante T.G., Flinders T., (2008), Cultivating mindfulness: effects on well-being, J Clin Psychol, 64 (7), p840-862.|
|67|| Silver M.H., Jilinskaia E., Perls T.T., (2001), Cognitive functional status of age-confirmed centenarians in a population-based study, J Gerontol B Psychol Sci Soc Sci, 56 (3), p134-140|
|68|| Singh A.R., Singh S.A., (2004), Health for all, All for health: Clichι, Dream or Commitment, MSM, 3 (2), p15-18. |
|69|| Singh A.R., Singh S.A., (2005), Emphasising prevention, developing therapies, complementing approaches, MSM, 3 (2), p15-18.|
|70|| Singh A.R., Singh S.A., (2006), To cure sometimes, to comfort always, to hurt the least, to harm never, MSM, 4 , p8-9.|
|71|| Singh A.R., Singh S.A., (2008), Diseases of Poverty and Lifestyle, Well-Being and Human Development, MSM, 6 (1), p187-225|
|72|| Singh A.R., Singh S.A., (2009), Notes on a few issues in the philosophy of psychiatry, MSM, 7 (1), p.128-183.|
|73|| Smith K.B., Pukall C.F., (2009), An evidence-based review of yoga as a complementary intervention for patients with cancer, Psychooncology, 18 (5), p465-475.|
|74|| Tomlinson M., Rudan I., Saxena S., Swartz L., Tsai AC., Patel V., (2009), Setting priorities for global mental health research, Bull World Health Organ, 87 (6), p438-446.|
|75|| Vaillant G.E., (2008), Positive Emotions, Spirituality and the Practice of Psychiatry, MSM, 6 (1), p48-62.|
|76|| van der Watt G., Laugharne J., Janca A., (2008), Complementary and alternative medicine in the treatment of anxiety and depression, Curr Opin Psychiatry, 21 (1), p37-42. |
|77||Willcox D.C., Willcox B.J., Shimajiri S., Kurechi S., Suzuki M., (2007), Aging gracefully: a retrospective analysis of functional status in Okinawan centenarians, Am J Geriatr Psychiatry, 15 (3), p252-256.|
|78|| Xiao Z., Xu Q., Yuan Y., (1996), Solving the mystery of the status and longevity of centenarians in Bama, Chin J Popul Sci, 8 (4), p385-394.|
|79||Ye J.J., Li J.C., Peng L., Gong Y.Y., Xie L., Lian S.G., Yang Z., Zhou Y.F., (2009), Nonagenarians and centenarians in a rural Han Chinese population: lifestyle and epidemics, J Am Geriatr Soc, 57 (9), p1723-1724.|