Home ~ About us ~ Ahead of print ~ Current Issue ~ Back Issues ~ Search ~ Instructions ~ Subscription ~ Advertise ~ Feedback ~ Login  
  Mens Sana Monographs
A Monograph Series Devoted To The Understanding Of Medicine, Mental Health, Man, Mind, Music And Their Matrix
 Why MSM | Acknowledgement | Call for papers... | Forthcoming MSM...  Users online: 341  Home Email this article Print this Article Bookmark this page Decrease font size Default font size Increase font size 
EDITORIAL
Year : 2012  |  Volume : 10  |  Issue : 1  |  Page : 4-12

Psychopharmacology of schizophrenia: The future looks bleak


1 M.D. Professor and Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore-560 029, India
2 M.D. Postdoctoral Associate, Dept of Psychiatry, Yale University School of Medicine, New Haven, CT- 06511, USA
3 M.D. Associate Professor of Psychiatry, Department of Psychiatry, Creighton University School of Medicine, 3528 Dodge Street, Omaha, NE 68131, USA

Correspondence Address:
Chittaranjan Andrade
M.D. (Psychiatry), Professor and Head, Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore 560 029
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1229.91293

Rights and Permissions

Introduction: More than half a century after the introduction of effective pharmacotherapy for the illness, in most patients schizophrenia remains a chronic, relapsing condition with poor long-term outcomes. Methods: We examine the pharmacological treatment of schizophrenia from different perspectives to understand why there have not been significant advances, and to consider what the future might hold in store. Results: We argue that the treatment of schizophrenia addresses the phenotype and not the cause; that the causes may not be treatable even if identifiable; that secondary prevention approaches involving treating the phenotype before full-fledged illness develops have, so far, not yielded promising results; and that shifting the focus of treatment from dopamine to other neurotransmitter systems is merely a tertiary prevention approach which will not reverse the extensive structural and functional pathology of schizophrenia. Conclusions: We believe that, given the current state of our knowledge of the illness, the future of the pharmacotherapy of schizophrenia looks bleak.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5207    
    Printed366    
    Emailed0    
    PDF Downloaded162    
    Comments [Add]    
    Cited by others 3    

Recommend this journal